The Panagia Faneromeni in Thessaloniki, located at the borders of the Center - Upper Town - Sykies, represents an emerging real estate micro-market with strong value-add potential. The central location, direct access to Vardaris / Democracy Square and the axes of Egnatia - Monastiriou - Lagada, as well as dense transportation networks, enhance rental demand from students, young professionals, and digital nomads. The property inventory mainly includes apartment buildings from the 1960-1980 period and ground-floor former shops, ideal for renovation or conversion into lofts with high ceilings and wide frontage. Acquisition prices remain significantly lower than the key points of the Center, offering an attractive entry and margin for value increase through energy upgrades, layout redesign, and modern aesthetics. For investors, strategies such as buy-renew-rent, mid-term leases of 3-12 months, or small-scale co-living optimize the yield per sq.m., while proximity to Vardaris and the metro station supports absorption and liquidity. Critical selection factors are the micro-location within the block, floor and elevator, energy class, and legality of uses, especially in loft conversions. Overall, Panagia Faneromeni Thessaloniki combines affordable pricing, central lifestyle, and strong investment prospects for buyers seeking returns and long-term value.